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      <link:roleType roleURI="http://www.vaccitech.co.uk/role/DisclosureNatureOfBusinessAndBasisOfPresentation" id="DisclosureNatureOfBusinessAndBasisOfPresentation">
        <link:definition>10101 - Disclosure - Nature of Business and Basis of Presentation</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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      <link:roleType roleURI="http://www.vaccitech.co.uk/role/DisclosureSummaryOfSignificantAccountingPolicies" id="DisclosureSummaryOfSignificantAccountingPolicies">
        <link:definition>10201 - Disclosure - Summary of Significant Accounting Policies</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
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      <link:roleType roleURI="http://www.vaccitech.co.uk/role/DisclosureBusinessCombination" id="DisclosureBusinessCombination">
        <link:definition>10301 - Disclosure - Business Combination</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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      <link:roleType roleURI="http://www.vaccitech.co.uk/role/DisclosureForeignCurrencyTranslationInGeneralAndAdministrativeExpenses" id="DisclosureForeignCurrencyTranslationInGeneralAndAdministrativeExpenses">
        <link:definition>10401 - Disclosure - Foreign Currency Translation in General and Administrative Expenses</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.vaccitech.co.uk/role/DisclosureNetIncomeLossPerShare" id="DisclosureNetIncomeLossPerShare">
        <link:definition>10501 - Disclosure - Net Income/(Loss) Per Share</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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      <link:roleType roleURI="http://www.vaccitech.co.uk/role/DisclosurePropertyAndEquipmentNet" id="DisclosurePropertyAndEquipmentNet">
        <link:definition>10601 - Disclosure - Property and Equipment, Net</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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      <link:roleType roleURI="http://www.vaccitech.co.uk/role/DisclosureIntangibleAssetsNet" id="DisclosureIntangibleAssetsNet">
        <link:definition>10701 - Disclosure - Intangible assets, net</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.vaccitech.co.uk/role/DisclosurePrepaidAndOtherCurrentAssets" id="DisclosurePrepaidAndOtherCurrentAssets">
        <link:definition>10801 - Disclosure - Prepaid and other current assets</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.vaccitech.co.uk/role/DisclosureAccruedExpensesAndOtherCurrentLiabilities" id="DisclosureAccruedExpensesAndOtherCurrentLiabilities">
        <link:definition>10901 - Disclosure - Accrued Expenses and Other Current Liabilities</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.vaccitech.co.uk/role/DisclosureOutLicensesAndGrants" id="DisclosureOutLicensesAndGrants">
        <link:definition>11001 - Disclosure - Out-licenses and Grants</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.vaccitech.co.uk/role/DisclosureConvertibleLoanNotes" id="DisclosureConvertibleLoanNotes">
        <link:definition>11101 - Disclosure - Convertible loan notes</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.vaccitech.co.uk/role/DisclosureSeriesAndSeriesBShares" id="DisclosureSeriesAndSeriesBShares">
        <link:definition>11201 - Disclosure - Series A and Series B Shares</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.vaccitech.co.uk/role/DisclosureOrdinaryShares" id="DisclosureOrdinaryShares">
        <link:definition>11301 - Disclosure - Ordinary Shares</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.vaccitech.co.uk/role/DisclosureDeferredShares" id="DisclosureDeferredShares">
        <link:definition>11401 - Disclosure - Deferred shares</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.vaccitech.co.uk/role/DisclosureShareBasedCompensation" id="DisclosureShareBasedCompensation">
        <link:definition>11501 - Disclosure - Share-Based Compensation</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.vaccitech.co.uk/role/DisclosureIncomeTaxes" id="DisclosureIncomeTaxes">
        <link:definition>11601 - Disclosure - Income Taxes</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.vaccitech.co.uk/role/DisclosureCommitmentsAndContingencies" id="DisclosureCommitmentsAndContingencies">
        <link:definition>11701 - Disclosure - Commitments and Contingencies</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.vaccitech.co.uk/role/DisclosureEmployeeBenefitPlans" id="DisclosureEmployeeBenefitPlans">
        <link:definition>11801 - Disclosure - Employee Benefit Plans</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.vaccitech.co.uk/role/DisclosureRelatedPartyTransactions" id="DisclosureRelatedPartyTransactions">
        <link:definition>11901 - Disclosure - Related Party Transactions</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.vaccitech.co.uk/role/DisclosureSubsequentEvents" id="DisclosureSubsequentEvents">
        <link:definition>12001 - Disclosure - Subsequent Events</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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      <link:roleType roleURI="http://www.vaccitech.co.uk/role/DisclosureSummaryOfSignificantAccountingPoliciesPolicies" id="DisclosureSummaryOfSignificantAccountingPoliciesPolicies">
        <link:definition>20202 - Disclosure - Summary of Significant Accounting Policies (Policies)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.vaccitech.co.uk/role/DisclosureNetIncomeLossPerShareTables" id="DisclosureNetIncomeLossPerShareTables">
        <link:definition>30503 - Disclosure - Net Income/(Loss) Per Share (Tables)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.vaccitech.co.uk/role/DisclosurePropertyAndEquipmentNetTables" id="DisclosurePropertyAndEquipmentNetTables">
        <link:definition>30603 - Disclosure - Property and Equipment, Net (Tables)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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      <link:roleType roleURI="http://www.vaccitech.co.uk/role/DisclosurePrepaidAndOtherCurrentAssetsTables" id="DisclosurePrepaidAndOtherCurrentAssetsTables">
        <link:definition>30803 - Disclosure - Prepaid and other current assets (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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      <link:roleType roleURI="http://www.vaccitech.co.uk/role/DisclosureAccruedExpensesAndOtherCurrentLiabilitiesTables" id="DisclosureAccruedExpensesAndOtherCurrentLiabilitiesTables">
        <link:definition>30903 - Disclosure - Accrued Expenses and Other Current Liabilities (Tables)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.vaccitech.co.uk/role/DisclosureOutLicensesAndGrantsTables" id="DisclosureOutLicensesAndGrantsTables">
        <link:definition>31003 - Disclosure - Out-licenses and Grants (Tables)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.vaccitech.co.uk/role/DisclosureConvertibleLoanNotesTables" id="DisclosureConvertibleLoanNotesTables">
        <link:definition>31103 - Disclosure - Convertible loan notes (Tables)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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      <link:roleType roleURI="http://www.vaccitech.co.uk/role/DisclosureOrdinarySharesTables" id="DisclosureOrdinarySharesTables">
        <link:definition>31303 - Disclosure - Ordinary Shares (Tables)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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      <link:roleType roleURI="http://www.vaccitech.co.uk/role/DisclosureIncomeTaxesTables" id="DisclosureIncomeTaxesTables">
        <link:definition>31603 - Disclosure - Income Taxes (Tables)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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      <link:roleType roleURI="http://www.vaccitech.co.uk/role/DisclosureCommitmentsAndContingenciesTables" id="DisclosureCommitmentsAndContingenciesTables">
        <link:definition>31703 - Disclosure - Commitments and Contingencies (Tables)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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      <link:roleType roleURI="http://www.vaccitech.co.uk/role/DisclosureNatureOfBusinessAndBasisOfPresentationDetails" id="DisclosureNatureOfBusinessAndBasisOfPresentationDetails">
        <link:definition>40101 - Disclosure - Nature of Business and Basis of Presentation (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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        <link:definition>40201 - Disclosure - Summary of Significant Accounting Policies - Foreign currency translation (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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        <link:definition>40203 - Disclosure - Summary of Significant Accounting Policies - Cash and cash equivalents (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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        <link:definition>40205 - Disclosure - Summary of Significant Accounting Policies - Allowance for credit losses (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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      <link:roleType roleURI="http://www.vaccitech.co.uk/role/DisclosureSummaryOfSignificantAccountingPoliciesImpairmentOfLongLivedAssetsDetails" id="DisclosureSummaryOfSignificantAccountingPoliciesImpairmentOfLongLivedAssetsDetails">
        <link:definition>40208 - Disclosure - Summary of Significant Accounting Policies - Impairment of long-lived assets (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
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        <link:usedOn>link:definitionLink</link:usedOn>
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        <link:definition>40302 - Disclosure - Business Combination - changes in goodwill (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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        <link:definition>40401 - Disclosure - Foreign Currency Translation in General and Administrative Expenses (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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        <link:definition>41002 - Disclosure - Out-licenses and Grants - Changes in the contract liabilities (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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        <link:definition>41302 - Disclosure - Ordinary Shares - Ordinary shares for future issuance (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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        <link:definition>41503 - Disclosure - Share-Based Compensation - Summary of stock option activity (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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        <link:definition>41702 - Disclosure - Commitments and Contingencies - Additional information (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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      <link:roleType roleURI="http://www.vaccitech.co.uk/role/DisclosureEmployeeBenefitPlansDetails" id="DisclosureEmployeeBenefitPlansDetails">
        <link:definition>41801 - Disclosure - Employee Benefit Plans (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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  <xsd:element id="vacc_StockIssuedDuringPeriodSharesIssueOfDeferredShares" name="StockIssuedDuringPeriodSharesIssueOfDeferredShares" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="vacc_DeferredStockParOrStatedValuePerShare" name="DeferredStockParOrStatedValuePerShare" nillable="true" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" />
  <xsd:element id="vacc_DeferredStockSharesAuthorized" name="DeferredStockSharesAuthorized" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" />
  <xsd:element id="vacc_DeferredStockSharesIssued" name="DeferredStockSharesIssued" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" />
  <xsd:element id="vacc_DeferredStockSharesOutstanding" name="DeferredStockSharesOutstanding" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" />
  <xsd:element id="vacc_NonCashInterestExpenseOnConvertibleLoanNotes" name="NonCashInterestExpenseOnConvertibleLoanNotes" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="vacc_IncreaseDecreaseInResearchAndDevelopmentIncentivesReceivable" name="IncreaseDecreaseInResearchAndDevelopmentIncentivesReceivable" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="vacc_PaymentsOfTransactionCostsForRedeemableConvertiblePreferredStock" name="PaymentsOfTransactionCostsForRedeemableConvertiblePreferredStock" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="vacc_PrepaidExpenseAndOtherAssetsCurrentTextBlock" name="PrepaidExpenseAndOtherAssetsCurrentTextBlock" nillable="true" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="vacc_AccruedLiabilitiesAndOtherCurrentLiabilitiesTextBlock" name="AccruedLiabilitiesAndOtherCurrentLiabilitiesTextBlock" nillable="true" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="vacc_AccruedLiabilitiesAndOtherCurrentLiabilitiesTableTextBlock" name="AccruedLiabilitiesAndOtherCurrentLiabilitiesTableTextBlock" nillable="true" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="vacc_AccruedManufacturingAndClinicalExpensesCurrent" name="AccruedManufacturingAndClinicalExpensesCurrent" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <xsd:element id="vacc_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityForeignExchangeTranslation" name="FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityForeignExchangeTranslation" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="vacc_OrdinarySharesLiquidationPreference" name="OrdinarySharesLiquidationPreference" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <xsd:element id="vacc_TemporaryEquitySharesIssuedUponConversion" name="TemporaryEquitySharesIssuedUponConversion" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="vacc_ShareholderUniversityOfOxfordMember" name="ShareholderUniversityOfOxfordMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="vacc_OxfordUniversityInnovationLimitedMember" name="OxfordUniversityInnovationLimitedMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="vacc_ClinicalStudyCostsMember" name="ClinicalStudyCostsMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="vacc_DebtInstrumentConvertibleConversionPriceMultiplier" name="DebtInstrumentConvertibleConversionPriceMultiplier" nillable="true" type="xbrli:pureItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="vacc_DebtInstrumentConvertibleBeneficialConversionAndRedemptionFeature" name="DebtInstrumentConvertibleBeneficialConversionAndRedemptionFeature" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="vacc_RedeemableNoncontrollingInterestDisclosureTextBlock" name="RedeemableNoncontrollingInterestDisclosureTextBlock" nillable="true" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="vacc_DeferredBSharesMember" name="DeferredBSharesMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="vacc_TemporaryEquityStockIssuedDuringPeriodValueNewIssuesGross" name="TemporaryEquityStockIssuedDuringPeriodValueNewIssuesGross" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="vacc_TemporaryEquityStockIssuanceCosts" name="TemporaryEquityStockIssuanceCosts" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="vacc_InLicenseAgreementsMember" name="InLicenseAgreementsMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="vacc_PercentageOfFutureRoyaltiesForDirectSalesOfCoveredProductLicenseAgreement" name="PercentageOfFutureRoyaltiesForDirectSalesOfCoveredProductLicenseAgreement" nillable="true" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="vacc_LesseeOperatingLeaseRightOfUseAssetAndOtherInformationTableTextBlock" name="LesseeOperatingLeaseRightOfUseAssetAndOtherInformationTableTextBlock" nillable="true" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="vacc_LesseeOperatingLeaseOtherInformationTableTextBlock" name="LesseeOperatingLeaseOtherInformationTableTextBlock" nillable="true" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="vacc_AmericanDepositarySharesMember" name="AmericanDepositarySharesMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="vacc_PercentageOfNetPaymentsReceivedForAllowableSublicensesOfTechnologyDevelopedLicenseAgreement" name="PercentageOfNetPaymentsReceivedForAllowableSublicensesOfTechnologyDevelopedLicenseAgreement" nillable="true" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="vacc_IssueOfSeriesBSharesNetOfIssuanceCosts" name="IssueOfSeriesBSharesNetOfIssuanceCosts" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="vacc_TemporaryEquitySharesConversionOfConvertibleSecuritiesInShares" name="TemporaryEquitySharesConversionOfConvertibleSecuritiesInShares" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="vacc_ConversionOfSeriesShares" name="ConversionOfSeriesShares" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="vacc_ConversionOfSeriesSharesInShares" name="ConversionOfSeriesSharesInShares" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="vacc_OfferingCosts" name="OfferingCosts" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="vacc_ConversionOfSeriesSharesEquity" name="ConversionOfSeriesSharesEquity" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="vacc_ConversionOfSeriesSharesEquityInShares" name="ConversionOfSeriesSharesEquityInShares" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="vacc_ConversionOfSeriesBShares" name="ConversionOfSeriesBShares" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="vacc_ConversionOfSeriesBSharesInShares" name="ConversionOfSeriesBSharesInShares" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="vacc_ConversionOfSeriesBSharesEquity" name="ConversionOfSeriesBSharesEquity" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="vacc_ConversionOfSeriesBSharesEquityInShares" name="ConversionOfSeriesBSharesEquityInShares" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="vacc_IncreaseDecreaseInEquityFromNoncontrollingInterest" name="IncreaseDecreaseInEquityFromNoncontrollingInterest" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" abstract="false" />
  <xsd:element id="vacc_StockholdersEquityDeferredSharesDisclosureTextBlock" name="StockholdersEquityDeferredSharesDisclosureTextBlock" nillable="true" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="vacc_NumberOfAmericanDepositarySharesAdsIssued" name="NumberOfAmericanDepositarySharesAdsIssued" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="vacc_IssuanceOfCommonStockUnderwritingCommissions" name="IssuanceOfCommonStockUnderwritingCommissions" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="vacc_IssuanceOfCommonStockOfferingCosts" name="IssuanceOfCommonStockOfferingCosts" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="vacc_PercentageOfSharesNecessaryToExercisePreemptiveRights" name="PercentageOfSharesNecessaryToExercisePreemptiveRights" nillable="true" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" />
  <xsd:element id="vacc_PeriodOfPreemptiveRightsToBeExercised" name="PeriodOfPreemptiveRightsToBeExercised" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="vacc_OxfordUniversityHospitalsMember" name="OxfordUniversityHospitalsMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="vacc_VaccitechPlcShareAwardPlan2021Member" name="VaccitechPlcShareAwardPlan2021Member" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="vacc_RestrictedShareUnitsStockOptionsShareAppreciationRightsAndRestrictedSharesMember" name="RestrictedShareUnitsStockOptionsShareAppreciationRightsAndRestrictedSharesMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="vacc_ShareBasedCompensationPercentageOfSharesAvailableForIssuanceAsPercentageOfIssuedAndOutstandingShares" name="ShareBasedCompensationPercentageOfSharesAvailableForIssuanceAsPercentageOfIssuedAndOutstandingShares" nillable="true" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="vacc_ExpirationOfShareBasedCompensationPlanFromDateOfInitialIssuance" name="ExpirationOfShareBasedCompensationPlanFromDateOfInitialIssuance" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="vacc_EnterpriseManagementIncentiveShareOptionSchemeMember" name="EnterpriseManagementIncentiveShareOptionSchemeMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="vacc_ContractWithCustomerLiabilityForeignExchangeTranslation" name="ContractWithCustomerLiabilityForeignExchangeTranslation" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="vacc_NumberOfSquareFeetUnderLeaseAgreement" name="NumberOfSquareFeetUnderLeaseAgreement" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="vacc_ShareholderOfOxfordSciencesEnterprisesPlcMember" name="ShareholderOfOxfordSciencesEnterprisesPlcMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="vacc_ResearchGrantsAndContractsMember" name="ResearchGrantsAndContractsMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="vacc_ResearchAndDevelopmentIncentiveIncomeExpense" name="ResearchAndDevelopmentIncentiveIncomeExpense" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="vacc_RouAssetsObtainedInExchangeForOperatingLeaseLiabilities" name="RouAssetsObtainedInExchangeForOperatingLeaseLiabilities" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element name="ScheduleOfOrdinarySharesReservedForFutureIssuanceTableTextBlock" id="vacc_ScheduleOfOrdinarySharesReservedForFutureIssuanceTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="MeasurementInputMarketCostOfDebtMember" id="vacc_MeasurementInputMarketCostOfDebtMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ProbabilityOfExerciseOfConversionFeatureOrCashRedemption" id="vacc_ProbabilityOfExerciseOfConversionFeatureOrCashRedemption" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPrepaidOtherCurrentAndNonCurrentAssets" id="vacc_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPrepaidOtherCurrentAndNonCurrentAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="BusinessCombinationConsiderationTransferredCashAndEquityInterest" id="vacc_BusinessCombinationConsiderationTransferredCashAndEquityInterest" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="ContingentConsiderationDependentOnConditions" id="vacc_ContingentConsiderationDependentOnConditions" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="ContingentConsiderationDependentOnLicenseOrSaleOfTechnology" id="vacc_ContingentConsiderationDependentOnLicenseOrSaleOfTechnology" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="LaboratoryEquipmentMember" id="vacc_LaboratoryEquipmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="EstimatedAmortizationExpenseOfIntangibleAssets" id="vacc_EstimatedAmortizationExpenseOfIntangibleAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="EmployeeRetentionAndPayrollTaxCreditCurrent" id="vacc_EmployeeRetentionAndPayrollTaxCreditCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="MinorityInterestPolicyTextBlock" id="vacc_MinorityInterestPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ClinicalTrialCostsPolicyTextBlock" id="vacc_ClinicalTrialCostsPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="AdditionalPaidInCapitalPolicyTextBlock" id="vacc_AdditionalPaidInCapitalPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ResearchAndDevelopmentIncentivesPolicyTextBlock" id="vacc_ResearchAndDevelopmentIncentivesPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="EffectiveIncomeTaxRateReconciliationProvisionToReturnAdjustments" id="vacc_EffectiveIncomeTaxRateReconciliationProvisionToReturnAdjustments" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="DeferredTaxAssetsLeasingArrangements" id="vacc_DeferredTaxAssetsLeasingArrangements" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="IncomeTaxDisclosureTable" id="vacc_IncomeTaxDisclosureTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="IncomeTaxDisclosureLineItem" id="vacc_IncomeTaxDisclosureLineItem" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ContractWithCustomerLiabilitiesTableTextBlock" id="vacc_ContractWithCustomerLiabilitiesTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="DeferredSharesAbstract" id="vacc_DeferredSharesAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="AgreementWithOxfordUniversityInnovationMember" id="vacc_AgreementWithOxfordUniversityInnovationMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="PercentageOfRoyaltiesOnNetSales" id="vacc_PercentageOfRoyaltiesOnNetSales" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="MaximumReimbursementAmountReceivable" id="vacc_MaximumReimbursementAmountReceivable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="ShareBasedPaymentArrangementPlanModificationSharesGranted" id="vacc_ShareBasedPaymentArrangementPlanModificationSharesGranted" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="VoltMember" id="vacc_VoltMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="RelatedPartyMember" id="vacc_RelatedPartyMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="OxfordUniversityInnovationMember" id="vacc_OxfordUniversityInnovationMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="EnaraBioMember" id="vacc_EnaraBioMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ScancellLtdMember" id="vacc_ScancellLtdMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ResearchAndDevelopmentIncentivesAbstract" id="vacc_ResearchAndDevelopmentIncentivesAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ConcentrationRiskThresholdPercentage" id="vacc_ConcentrationRiskThresholdPercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="DeferredTaxLiabilityNet" id="vacc_DeferredTaxLiabilityNet" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="CashConsiderationOnAcquisitionOfSubsidiaryPayable" id="vacc_CashConsiderationOnAcquisitionOfSubsidiaryPayable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="PurchasesOfPropertyAndEquipmentIncludedInAccountsPayableAndAccruedLiabilities" id="vacc_PurchasesOfPropertyAndEquipmentIncludedInAccountsPayableAndAccruedLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="AssetRetirementObligations" id="vacc_AssetRetirementObligations" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="ForeignCurrencyTransactionGainLossUnrealizedOnConvertibleLoanNotes" id="vacc_ForeignCurrencyTransactionGainLossUnrealizedOnConvertibleLoanNotes" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="ChangesToRightOfUseAssetResultingFromLeaseReassessmentEvent" id="vacc_ChangesToRightOfUseAssetResultingFromLeaseReassessmentEvent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="LesseeOperatingLeaseExtendedTerm" id="vacc_LesseeOperatingLeaseExtendedTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="LesseeOperatingLeaseReceivableToBeReceivedYearOne" id="vacc_LesseeOperatingLeaseReceivableToBeReceivedYearOne" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="NonCashLeaseExpenses" id="vacc_NonCashLeaseExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="CommonStockNumberOfVotesPerShare" id="vacc_CommonStockNumberOfVotesPerShare" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="LeaseIncentiveReceivablesCurrent" id="vacc_LeaseIncentiveReceivablesCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="TransferOfAssetsFromLevel1ToLevel2" id="vacc_TransferOfAssetsFromLevel1ToLevel2" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="TransferOfAssetsFromLevel2ToLevel1" id="vacc_TransferOfAssetsFromLevel2ToLevel1" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="TransferOfLiabilitiesFromLevel1ToLevel2" id="vacc_TransferOfLiabilitiesFromLevel1ToLevel2" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="TransferOfAssetsLiabilitiesInAndOutOfLevel3" id="vacc_TransferOfAssetsLiabilitiesInAndOutOfLevel3" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="TransferOfLiabilitiesFromLevel2ToLevel1" id="vacc_TransferOfLiabilitiesFromLevel2ToLevel1" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsIntangibles" id="vacc_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsIntangibles" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="AdjustmentsToAdditionalPaidInCapitalMeasurementPeriodAdjustmentsInBusinessCombination" id="vacc_AdjustmentsToAdditionalPaidInCapitalMeasurementPeriodAdjustmentsInBusinessCombination" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="AgreementWithScancellToGrantResearchAndDevelopmentLicenseMember" id="vacc_AgreementWithScancellToGrantResearchAndDevelopmentLicenseMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DeferredSharesTable" id="vacc_DeferredSharesTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DeferredSharesLineItems" id="vacc_DeferredSharesLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="CapitalizedResearchAndDevelopmentDomesticExpendituresAmortizationPeriod" id="vacc_CapitalizedResearchAndDevelopmentDomesticExpendituresAmortizationPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="CapitalizedResearchAndDevelopmentForeignExpendituresAmortizationPeriod" id="vacc_CapitalizedResearchAndDevelopmentForeignExpendituresAmortizationPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="BusinessCombinationsMeasurementsPeriodAdjustmentsDecreaseInOtherCurrentAssets" id="vacc_BusinessCombinationsMeasurementsPeriodAdjustmentsDecreaseInOtherCurrentAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="BusinessAcquisitionSharesReturnedPricePerShare" id="vacc_BusinessAcquisitionSharesReturnedPricePerShare" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ContingentConsiderationLiabilityMember" id="vacc_ContingentConsiderationLiabilityMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="BusinessCombinationContingentConsiderationAdditionalAmountPayable" id="vacc_BusinessCombinationContingentConsiderationAdditionalAmountPayable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="BusinessCombinationsMeasurementPeriodAdjustments" id="vacc_BusinessCombinationsMeasurementPeriodAdjustments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="DeferredShares.Member" id="vacc_DeferredShares.Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="BardaContractsMember" id="vacc_BardaContractsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ContingentConsiderationSettledInEquity" id="vacc_ContingentConsiderationSettledInEquity" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="U.s.BiomedicalAdvancedResearchAndDevelopmentAuthorityBarda.Member" id="vacc_U.s.BiomedicalAdvancedResearchAndDevelopmentAuthorityBarda.Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="AtMarketOfferingsUnderSaleAgreementWithJefferiesLlcMember" id="vacc_AtMarketOfferingsUnderSaleAgreementWithJefferiesLlcMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="NonCashInvestingAndFinancingActivityOfMeasurementPeriodAdjustments" id="vacc_NonCashInvestingAndFinancingActivityOfMeasurementPeriodAdjustments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="Avidea.Member" id="vacc_Avidea.Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="BusinessCombinationConsiderationsTransferredReturnOfEquitySecuritiesIssued" id="vacc_BusinessCombinationConsiderationsTransferredReturnOfEquitySecuritiesIssued" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="EffectiveIncomeTaxRateReconciliationTaxCreditsResearchAndDevelopment" id="vacc_EffectiveIncomeTaxRateReconciliationTaxCreditsResearchAndDevelopment" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="OuiLicenseAgreementAmendmentMember" id="vacc_OuiLicenseAgreementAmendmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ResearchAndDevelopmentServicesPolicyPolicyTextBlock" id="vacc_ResearchAndDevelopmentServicesPolicyPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
</xsd:schema>
